EVOLENCE® Collagen Filler
EVOLENCE® dermal filler represents a breakthrough in treating the effects of aging by replacing the collagen you've lost with collagen that lasts. A truly novel dermal filler, EVOLENCE® can immediately improve and refresh your appearance by smoothing out and softening unwanted wrinkles and folds, and restoring structure and facial contour in volume-depleted areas. The visible, natural-looking results are achieved immediately, with minimal-to-no downtime, so you can get right back to your daily activities. These immediate results last for at least 6 months, so you can avoid the costly repeat treatments often associated with other fillers.
EVOLENCE® is injected by Dr. Zimbler, and your desired results may be achieved in just 1 visit. Only Dr. Zimbler can determine the best treatment approach for achieving your desired results.
Why Is Collagen So Important For Achieving A More Youthful Appearance?
Collagen is nature's most fundamental and abundant building block. In fact, collagen makes up 70% to 80% of the skin's dermis, providing structure, strength, and support. Collagen depletes naturally over time as we age, leading to a tired or aged appearance. This happens through the formation of new wrinkles and folds, and changes in facial contour and structure. The natural pace of collagen loss can be accelerated by such factors as sun exposure, genetics, hormonal changes, and smoking.
By replacing lost collagen with an advanced collagen compound, EVOLENCE® dermal filler can help enhance and maintain the structure, volume, and naturally younger-looking appearance of your skin.
What Makes EVOLENCE® Different?
EVOLENCE® dermal filler is made of natural collagen, one of the most prevalent materials in your body. The advanced collagen in EVOLENCE® has been naturally cross-linked, so it mimics the 3-dimensional structure of your skin's own collagen. This allows it to integrate beautifully and support your skin's own existing collagen network by adding structure, strength, and volume for a natural look and feel that last.
The unique collagen of EVOLENCE®:
- Achieves immediate, natural-looking results, so you can walk out of your aesthetic professional's office looking beautifully refreshed
- Causes minimal-to-no swelling or bruising, so you can get right back to daily activities
- Last for at least 6 months so it is convenient and reduces costly repeat visits
- Does not require a skin pre-test, so you can get results in 1 visit
Although new to the US, EVOLENCE® has been used extensively in Canada, Europe, and Israel for several years.
Where Is EVOLENCE® Collagen Filler Used?
EVOLENCE® is recommended for the correction of moderate-to-deep facial wrinkles and folds, such as nasolabial folds, the ones that appear from your nose to the corners of your mouth ("smile lines").
What Is EVOLENCE® Collagen Filler Used For?
EVOLENCE® is injected into areas of facial tissue where moderate to deep facial wrinkles and folds occur.
Who Can Benefit From EVOLENCE® Collagen Filler Treatment?
EVOLENCE® may be appropriate for patients who want soft, supportive foundation to fill areas where there has been natural collagen loss. Your healthcare provider can help you determine if you are a good candidate for EVOLENCE® treatment.
Do I Need A Skin Test Before Using EVOLENCE® Collagen Filler?
No. Skin test study showed that reactions to EVOLENCE® are rare and, when they do occur, mild. Skin testing is not necessary prior to treatment. However, in case you have had an allergy to collagen product in the past (such as hives or swelling after eating porcine products) or serious recurrent nonspecific allergic reactions, please inform your Dr. Zimbler before treatment.
Are There Any Warnings For The Use Of EVOLENCE® Collagen Filler?
- EVOLENCE® should be used with caution in patients on immunosuppressive therapy (medication commonly prescribed for those who have undergone an organ transplant, or are suffering from rheumatoid arthritis, psoriasis, inflammatory bowel disease, or cancer).
- The safety and effectiveness of EVOLENCE® for the treatment of areas other than facial wrinkles and folds have not been established in controlled clinical studies.
- EVOLENCE® should be used with caution in patients with known connective tissue disease, such as rheumatoid arthritis, scleroderma or systemic lupus erythematosus, history of herpes.
- The safety of EVOLENCE® in pregnant or breastfeeding women as well as in patients under the age of 18 years has not been established.
Can EVOLENCE® Collagen Filler Be Used In The Skin OF Color Patients?
The safety of EVOLENCE® Collagen Filler in skin of color patients (i.e., individuals with skin tone of light brown to black) was studied for a limited time only (2 weeks to 3 months, 3 to 6 months, and greater than 6 months). EVOLENCE® should not be used in patients with known susceptibility to abnormal scarring or local changes in skin color. The safety of EVOLENCE® in patients susceptible to keloid formation, hyperpigmentation and hypertrophic scarring has not been established.t.
Who Should Not Use EVOLENCE® Collagen Filler?
- Patients with a known allergy from eating any pork collagen product
- Patients with a history of severe or multiple occurring allergies.
People with these conditions, if they use EVOLENCE®, may have an allergic reaction and experience swelling, redness, or pain. In rare instances, allergic reactions to some materials can be severe and require medical assistance. Although no such reaction has ever been observed following use of EVOLENCE®, patients having experienced past allergic reactions to pork products should be aware of their medical history and these risks.
How Does EVOLENCE® Collagen Filler Work?
The production of collagen in the body decreases as you get older and/or exposed to the sun. The first visible signs of this decrease in production are the development of wrinkles. EVOLENCE® works by replacing and restoring collagen in the dermal layer of the skin where it naturally exists. EVOLENCE® will be injected with a fine needle midway or deep into your skin to help fill the areas of lost collagen where moderate to deep facial wrinkles and folds occur.
How Is EVOLENCE® Collagen Filler Injected?
EVOLENCE® is injected beneath the wrinkle or fold into the dermal layer of the skin using a fine needle.
Do EVOLENCE® Collagen Filler Injections Hurt?
Dermal fillers often require more than one injection during a treatment session to obtain an optimal result. The use of a needle to inject a product like a dermal filler can be associated with local skin discomfort. Certain areas of the face are more sensitive than others and your healthcare provider may choose either an external and/or local injectable anesthetic to help prevent discomfort and pain. Discuss pain management with Dr. Zimbler.
Are The Results From EVOLENCE® Collagen Filler Immediate?
Yes. The natural collagen structure of EVOLENCE® fills the space of the depleted collagen and decreases the appearance of wrinkles, so it immediately gives the skin a smoother appearance.
How Many Treatments of EVOLENCE® Collagen Filler Are Required?
One treatment with EVOLENCE® may be all that is required to achieve optimal wrinkle smoothing. The decision for additional treatments with EVOLENCE® is left up to you and your healthcare provider. Dr. Zimbler provider will generally like to see you within two weeks of the first treatment to assess your satisfaction and to measure the success of treatment. Following your initial treatment, you and your healthcare provider will determine when future injections are needed.
How Long Does EVOLENCE® Collagen Filler Last?
The length of time that EVOLENCE® lasts in the body may vary from patient to patient. The duration may also depend on the amount of EVOLENCE® injected and the injected area. Information from a US clinical trial has shown that 97% of the patients maintained the effects of EVOLENCE® for at least 6 months. Data gained from animal studies, foreign clinical studies and usage of EVOLENCE® in other countries have demonstrated that EVOLENCE® has lasted for up to 12 months.
What Can I Expect To Happen At An EVOLENCE® Treatment Session?
- Dr. Zimbler will answer any questions you have before your treatment.
- Remove all make-up prior to your treatment.
- An antiseptic will be used to clean all of the areas to be treated.
- Local anesthetics will be used if needed.
- Small amounts of EVOLENCE® will be injected into the skin.
- You will then receive instructions on how to care for the treated area once you leave the office.
What Can I Expect After An EVOLENCE® Collagen Filler Treatment?
Immediately after your treatment, the injection sites may be painful and red or swollen. These site reactions are typically mild and go away with time, usually within hours to a few days. Follow the post-treatment directions given to you by your healthcare provider. If a side effect lasts longer than expected and is of concern to you, contact your healthcare provider. You might have a mild to moderate reaction at the injection site, but that should clear up in a few days.
You should follow these instructions.
Within the first 24-48 hours you should avoid:
- Strenuous exercise
- Excessive sun, extreme heat, or extreme cold exposure
- Alcoholic beverages
- Exposure to any of the above may cause temporary redness, swelling, or itching at the injection site.
What Should I Tell Dr. Zimbler About The Medicines I Take?
Talk with Dr. Zimbler about all medications that you are taking. In addition, discuss over-the-counter medications and natural products that you are using on a regular basis. It is also recommended that you tell your doctor about other fillers or procedures you have had in the past. If you are taking a blood thinner or medications that may interfere with clotting of the blood such as aspirin, Ibuprofen or Vitamin E products, you may be more likely to develop bruising at the sites of injection.
No formal drug interaction studies have been done with EVOLENCE®. Talk with your Dr. Zimbler about your medical history prior to deciding on a specific treatment.
When Should I Notify Dr. Zimbler If I Have Concerns?
Any side effect that lasts longer than a week should be reported to your healthcare provider. Call your healthcare provider if you are concerned about your side effect or think that you have a complication.
How Quickly Can I Get Back To My Activities?
The majority of patients who receive EVOLENCE® collagen filler injections continue with their daily activities following treatment. However, during the first 24-48 hours after treatment, exposure to extremes of temperature (hot or cold) or strong sunlight should be avoided to reduce risk of inflammation. After this time you can go about your normal daily activities with no other treatment required.
When Will I Be ABle TO Apply Make-up After My EVOLENCE® Injections?
Do not apply make-up immediately after treatment to avoid any complications and to keep the treated area clean. You should ask your healthcare provider when make-up may be applied after treatment.
Is EVOLENCE® Collagen Filler Treatment Right For Me?
Dr. Zimbler will help you determine the best treatment approach for achieving your desired results. Together, you may decide EVOLENCE® dermal filler is right for you if you are seeking a refreshed and naturally younger-looking you. The visible results are immediate—with minimal-to-no downtime post-treatment— and lasts at least 6 months.
How to get started with EVOLENCE®?
Marc S. Zimbler, MD and his staff will be happy to discuss EVOLENCE® with you. Please call for a private consultation or schedule an appointment online at our office.
Flexible & interest free financing available
We are pleased to offer affordable financing options. Choose from a variety of installment and interest free payment plans and, upon approval, start your treatment today. Visit our patient financing section of our website or call us @ 212.570.9900 to find out more details.



